The Van Wyck Homestead Museum or Van Wyck-Wharton House is an early 18th-century Dutch colonial house in the Town of Fishkill, New York, United States of America. It served as a headquarters to a major military supply depot during the American Revolutionary War and has been listed on the National Register of Historic Places since April 13, 1972; the adjoining Fishkill Supply Depot Site has been listed on the NRHP since January 21, 1974. It is located on US 9 just south of Interstate 84. Excavations during the construction of a nearby gas station and the Dutchess Mall in the early 1970s unearthed many artifacts at the site, particularly materiel.